Literature Review: Fermented Dairy Food Effect on Cardiovascular Biomarker

Main Article Content

Ivan Bardika
Aryanti R. Bamahry
Dian Fahmi Utami
Fadillah Maricar
Akina Maulidhany Tahir

Abstract

Fermented dairy products are functional foods rich in probiotics, bioactive peptides, and nutrients that may provide cardiovascular health benefits. However, evidence regarding their effects on cardiovascular biomarkers remains inconsistent. This study reviewed scientific evidence on the effects of fermented dairy products on cardiovascular biomarkers. A literature review was conducted using national and international publications published between 2020 and 2026. Literature searches were performed through PubMed, Google Scholar, ScienceDirect, SpringerLink, ProQuest, and ResearchGate. Eligible studies were analyzed narratively by summarizing, synthesizing, comparing, contrasting, and critically evaluating their findings. A total of 17 scientific articles met the inclusion criteria and were analyzed. The findings indicate that fermented dairy products, particularly yogurt, kefir, and cheese, may improve cardiovascular biomarkers by reducing total cholesterol and low-density lipoprotein (LDL) levels, increasing high-density lipoprotein (HDL) levels, and decreasing inflammatory biomarkers such as C-reactive protein (CRP). They may also improve glycemic control, modulate gut microbiota by increasing short-chain fatty acid (SCFA)-producing bacteria, and reduce cardiovascular disease risk. However, effects vary according to product type, probiotic composition, dosage, intervention duration, and participant characteristics. Overall, fermented dairy products show potential to support cardiovascular health through improvements in lipid profiles, inflammation, gut microbiota, and glycemic control. Further large-scale clinical trials and well-designed interventions are needed to establish causal relationships and determine optimal consumption strategies.

Article Details

How to Cite
Bardika, I., Bamahry , A. R. ., Utami, D. F. ., Maricar, F. ., & Tahir, A. M. . (2026). Literature Review: Fermented Dairy Food Effect on Cardiovascular Biomarker. Journal of Community Health Provision, 6(3), 931-949. https://doi.org/10.55885/jchp.v6i3.1079
Section
Articles

References

Agyei, D., Owusu-Kwarteng, J., Akabanda, F., & Akomea-Frempong, S. (2020). Indigenous African fermented dairy products: Processing technology, microbiology and health benefits. Critical reviews in food science and nutrition, 60(6), 991-1006. https://doi.org/10.1080/10408398.2018.1555133

Bintsis, T., & Papademas, P. (2022). The evolution of fermented milks, from artisanal to industrial products: A critical review. Fermentation, 8(12), 679. https://doi.org/10.3390/fermentation8120679

Cetik Yildiz, S., Demir, C., Cengiz, M., Irmak, H., Cengiz, B. P., & Ayhanci, A. (2024). In vitro antitumor and antioxidant capacity as well as ameliorative effects of fermented kefir on cyclophosphamide-induced toxicity on cardiac and hepatic tissues in rats. Biomedicines, 12(6), 1199. https://doi.org/10.3390/biomedicines12061199

Chen, L., Bagnicka, E., Chen, H., & Shu, G. (2023). Health potential of fermented goat dairy products: composition comparison with fermented cow milk, probiotics selection, health benefits and mechanisms. Food & function, 14(8), 3423-3436. https://doi.org/10.1039/d3fo00413a

Companys, J., Pedret, A., Valls, R. M., Sola, R., & Pascual, V. (2021). Fermented dairy foods rich in probiotics and cardiometabolic risk factors: a narrative review from prospective cohort studies. Critical reviews in food science and nutrition, 61(12), 1966-1975. https://doi.org/10.1080/10408398.2020.1768045

Companys, J., Pla-Pagà, L., Calderón-Pérez, L., Llauradó, E., Solà, R., Pedret, A., & Valls, R. M. (2020). Fermented dairy products, probiotic supplementation, and cardiometabolic diseases: a systematic review and meta-analysis. Advances in nutrition, 11(4), 834-863.

Derosa, G., Colletti, A., Maffioli, P., D’Angelo, A., Lupi, A., Zito, G. B., ... & Cicero, A. F. (2020). Lipid-lowering nutraceuticals update on scientific evidence. Journal of Cardiovascular Medicine, 21(11), 845-859.

Djaja, N., Soekiono, C. J., & Vanessa, I. (2025). Efek Asam Lemak Omega-3 pada Pemulihan dari Prosedur Kardiovaskular: The Effects of Omega-3 Fatty Acids on Recovery from Cardiovascular Procedures. Jurnal Sains dan Kesehatan, 6(3), 176-187.

Fajriani, L. N., Sukanty, N. M. W., Isasih, W. D., Anggriany, N., & Najiyyah, S. U. (2025). Pengaruh Produk Olahan Susu Fermentasi terhadap Risiko Penyakit Kardiovaskular. Jurnal Kolaboratif Sains, 8(7), 4191-4197. https://doi.org/10.56338/jks.v8i7.7892

García-Burgos, M., Moreno-Fernández, J., Alférez, M. J., Díaz-Castro, J., & López-Aliaga, I. (2020). New perspectives in fermented dairy products and their health relevance. Journal of Functional Foods, 72, 104059.

Guasch-Ferré, M., Tessier, A. J., Petersen, K. S., Sapp, P. A., Tapsell, L. C., Salas-Salvadó, J., ... & Kris-Etherton, P. M. (2023). Effects of nut consumption on blood lipids and lipoproteins: a comprehensive literature update. Nutrients, 15(3), 596. https://doi.org/10.3390/nu15030596

Harjo, V. A., & Doloksaribu, T. H. (2023). PENGARUH KONSUMSI PANGAN FERMENTASI TERHADAP PROFIL LIPID DARAH: STUDI LITERATUR. Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist), 18(1), 51-62. https://doi.org/10.36911/pannmed.v18i1.1540

Kanetro, B., Slamet, A., & Budiyanto, C. (2021). Potensi Minuman Fungsional Berbasis Susu Dengan Isolat Biji Atau Kecambah Koro Pedang Dalam Pencegahan Penyakit Kardiovaskular. Jurnal Teknologi Pertanian, 22(3), 187-200. https://doi.org/10.21776/ub.jtp.2021.022.03.4

Kaur, H., Kaur, G., & Ali, S. A. (2022). Dairy-based probiotic-fermented functional foods: An update on their health-promoting properties. Fermentation, 8(9), 425. https://doi.org/10.3390/fermentation8090425

Khan, I. T., Nadeem, M., Imran, M., Ullah, R., Ajmal, M., & Jaspal, M. H. (2019). Antioxidant properties of Milk and dairy products: A comprehensive review of the current knowledge. Lipids in health and disease, 18(1), 41. https://doi.org/10.1186/s12944-019-0969-8

La Barbera, G., Praticò, G., Dragsted, L. O., & Cuparencu, C. (2024). Metabolomics-based biomarkers of fermented dairy and red meat intake: a randomized controlled trial in healthy adults. Frontiers in Chemistry, 12, 1461331. https://doi.org/10.3389/fchem.2024.1461331

Lordan, R., Tsoupras, A., Mitra, B., & Zabetakis, I. (2018). Dairy fats and cardiovascular disease: do we really need to be concerned?. Foods, 7(3), 29. https://doi.org/10.3390/foods7030029

Machlik, M. L., Hopstock, L. A., Wilsgaard, T., & Hansson, P. (2021). Associations between intake of fermented dairy products and blood lipid concentrations are affected by fat content and dairy matrix–The Tromsø study: Tromsø7. Frontiers in nutrition, 8, 773468. https://doi.org/10.3389/fnut.2021.773468

Markowiak-Kopeć, P., & Śliżewska, K. (2020). The effect of probiotics on the production of short-chain fatty acids by human intestinal microbiome. Nutrients, 12(4), 1107. https://doi.org/10.3390/nu12041107

Michaëlsson, K., Lemming, E. W., Larsson, S. C., Höijer, J., Melhus, H., Svennblad, B., ... & Byberg, L. (2024). Non-fermented and fermented milk intake in relation to risk of ischemic heart disease and to circulating cardiometabolic proteins in swedish women and men: Two prospective longitudinal cohort studies with 100,775 participants. BMC medicine, 22(1), 483. https://doi.org/10.1186/s12916-024-03651-1

Nwadi, O. M., Okoyeuzu, C. F., Okechukwu, Q. N., Uchegbu, N. N., Okonkwo, T. M., & Okpala, C. O. R. (2026). Fermentation intricacies involving dairy milk and their bioactive, health, microbial, and product challenges: A terse review. Quality Assurance and Safety of Crops & Foods, 18(2), 87-113. https://doi.org/10.15586/qas.v18i2.1605

Oktay, Y. (2023). A review of fermented milks: potential beneficial effects on human nutrition and health. African Health Sciences, 23(4), 498-507. https://doi.org/10.4314/ahs.v23i4.54

Pourrajab, B., Naderi, N., Janani, L., Mofid, V., Hajahmadi, M., Dehnad, A., & Shidfar, F. (2020). Comparison of probiotic yogurt and ordinary yogurt consumption on serum Pentraxin3, NT-proBNP, oxLDL, and ApoB100 in patients with chronic heart failure: a randomized, triple-blind, controlled trial. Food & function, 11(11), 10000-10010.

Rajta, P., Bajaj, A., Sharma, S., Regassa, H., & Gudeta, K. (2023). Bio-production of fermented dairy products and health benefits: a review of the current scenario and prospects. International Journal of Agricultural Sciences and Technology (IJAGST), 3(2), 18-38. https://doi.org/10.22004/ag.econ.344704

Rashidbeygi, E., Samarin, M. M., Sheikhhossein, F., Khalilkhaneh, A. H., Gholizadeh, M., Lohrasbi, N., ... & Amini, M. R. (2025). The Effect of Kefir Consumption on Blood Pressure and C‐Reactive Protein: A Systematic Review and Meta‐Analysis of Randomised Controlled Trials. Endocrinology, diabetes & metabolism, 8(6), e70124. https://doi.org/10.1002/edm2.70124

Rendon-Rosales, M. A., Méndez-Romero, J. I., Hernández-Mendoza, A., González-Córdova, A. F., Mazorra-Manzano, M. A., García, H. S., ... & Vallejo-Cordoba, B. (2024). Gut microbiota response to consumption of milks fermented with specific strains of Lactococcus lactis with hypocholesterolemic effect. Food Production, Processing and Nutrition, 6(1), 58. https://doi.org/10.1186/s43014-024-00221-z

Sahala, J., Simamora, T., Chrisinta, D., Abi, A. P. T., Seran, M. M., & Ninu, M. M. (2024). Edukasi Pentingnya Minum Susu Bagi Masyarakat Di Desa Oenenu, Kecamatan Bikomi Tengah Kabupaten Timor Tengah Utara. Proficio, 5(1), 660-666. https://doi.org/10.36728/jpf.v5i1.3194

Saleem, G. N., Gu, R., Qu, H., Bahar Khaskheli, G., Rashid Rajput, I., Qasim, M., & Chen, X. (2024). Therapeutic potential of popular fermented dairy products and its benefits on human health. Frontiers in Nutrition, 11, 1328620. https://doi.org/10.3389/fnut.2024.1328620

Salsabilla, A. S., Safitri, A., & Bima, I. H. (2025). Pengaruh Konsumsi Produk Susu Fermentasi Terhadap Profil Lipid Pada Individu Obesitas.

Sharma, H., Ozogul, F., Bartkiene, E., & Rocha, J. M. (2023). Impact of lactic acid bacteria and their metabolites on the techno-functional properties and health benefits of fermented dairy products. Critical Reviews in Food Science and Nutrition, 63(21), 4819-4841. https://doi.org/10.1080/10408398.2021.2007844

Sionek, B., Szydłowska, A., Küçükgöz, K., & Kołożyn-Krajewska, D. (2023). Traditional and new microorganisms in lactic acid fermentation of food. Fermentation, 9(12), 1019. https://doi.org/10.3390/fermentation9121019

Stadler, J. T., & Marsche, G. (2021). Dietary strategies to improve cardiovascular health: focus on increasing high-density lipoprotein functionality. Frontiers in nutrition, 8, 761170. https://doi.org/10.3389/fnut.2021.761170

Trieu, K., Bhat, S., Dai, Z., Leander, K., Gigante, B., Qian, F., ... & Marklund, M. (2021). Biomarkers of dairy fat intake, incident cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis. PLoS medicine, 18(9), e1003763. https://doi.org/10.1371/journal.pmed.1003763

Velissaridou, A., Panoutsopoulou, E., Prokopiou, V., & Tsoupras, A. (2024). Cardio-protective-promoting properties of functional foods inducing HDL-cholesterol levels and functionality. Nutraceuticals, 4(4), 469-502. https://doi.org/10.3390/nutraceuticals4040028

Wiryani, L. P. L., & Yustiantara, P. S. (2023, November). Pengolahan dan Pengembangan Oat (Avena sativa L.) Menjadi Susu Nabati Rendah Lemak Bagi Penderita Hiperkolesterolemia. In Prosiding Workshop Dan Seminar Nasional Farmasi (Vol. 2, pp. 449-463). https://doi.org/10.24843/WSNF.2022.v02.p36

Yang, R., Pang, J., Zhong, X., Pang, S., Hu, X., Wei, C., ... & Cao, Z. (2025). Molecular mechanisms of aberrant fatty acids metabolism in driving cardiovascular diseases: key regulatory targets and dietary interventions. Food & function, 16(15), 5961-5993. https://doi.org/10.1039/d5fo01237f

Yilmaz, B., Alvanoudi, P., Kalogeropoulou, A., Santa, D., Bulmuş-Tüccar, T., Nikolaou, A., ... & Mantzouridou, F. T. (2025). Fermented dairy product consumption and blood lipid levels in healthy adults: a systematic review. Frontiers in Nutrition, 12, 1651134. https://doi.org/10.3389/fnut.2025.1651134

Zakeri, A., Saberi, M., Hussain, O. K., & Chang, E. (2018). An early detection system for proactive management of raw milk quality: An Australian case study. IEEE Access, 6, 64333-64349. https://doi.org/10.1109/ACCESS.2018.2877970

Zhang, X., Luo, Q., Guan, X., Tang, Y., Chen, X., Deng, J., & Fan, J. (2023). Effects of fermented dairy products on inflammatory biomarkers: A meta-analysis. Nutrition, Metabolism and Cardiovascular Diseases, 33(3), 471-482. https://doi.org/10.1016/j.numecd.2022.12.014

Zhong, H., Wang, L., Jia, F., Yan, Y., Xiong, F., Hidayat, K., & Li, Y. (2024). Effect of probiotic fermented milk supplementation on glucose and lipid metabolism parameters and inflammatory markers in patients with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Biology, 13(8), 641. https://doi.org/10.3390/biology13080641