The Effect of Giving D-Galactose as an Aging Inducer on Body Weight, Glucose Levels and Interleukin-6 Levels in Wistar Rats

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Published: Apr 11, 2025
DOI: https://doi.org/10.55885/jchp.v5i1.556
Keywords:
D-Galactose, Aging, Body Weight, Glucose, Interleukin, Wistar Rats

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Arlina Wiyata Gama
Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Islam Negeri Alauddin Makassar, Makassar, Indonesia
Rahmawati Akib
Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Islam Negeri Alauddin Makassar, Makassar, Indonesia
Ummul Khaera
Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Islam Negeri Alauddin Makassar, Makassar, Indonesia

Abstract

Aging is a complex biological process, characterized by decreased physiological function and increased susceptibility to chronic disease. D-Galactose was used as an aging induction agent in Wistar rats to assess its impact on body weight, blood glucose levels, and interleukin-6 (IL-6) levels. D-Galactose, although a normal monosaccharide, can accelerate aging through increased oxidative stress and inflammation, characterized by increased ROS and IL-6. This study aims to analyze the changes that occur as a result of D-Galactose administration, which can provide insight into the mechanisms of aging and the potential for developing therapies for age-related diseases. It is hoped that this research will contribute to the understanding and management of the challenges of aging in the context of human health. This research was an experimental study with a pre and post test design, involving 20 male Wistar rats divided into two groups: a treatment group that received D-Galactose 150 mg/kgBW and a control group that received 0.9% NaCL, both for 6 Sundays. The research was conducted at the PSPD Research Laboratory FKIK UIN Alauddin Makassar from August to October 2024. The mice had their body weight, blood glucose levels after overnight fasting and serum IL-6 levels measured every week using ELISA. Variables analyzed included body weight, blood glucose levels, and IL-6 levels, with controls for age, sex, strain, feed, drinking water, and housing conditions. Data were analyzed using the independent t-test, with a p value < 0.05 considered statistically significant.

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Gama, A. W., Akib, R. ., & Khaera, U. . (2025). The Effect of Giving D-Galactose as an Aging Inducer on Body Weight, Glucose Levels and Interleukin-6 Levels in Wistar Rats . Journal of Community Health Provision, 5(1), 1-8. https://doi.org/10.55885/jchp.v5i1.556
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Vol. 5 No. 1 (2025): Journal of Community Health Provision
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