Evaluation of the Clinical Picture and Effectiveness of Antifungal Therapy in Tinea Corporis Cases in Tropical Areas: Literature Review

Main Article Content

Anniza Putri Abduh
Dian Amelia Abdi
Solehca Setiawati

Abstract

Tinea corporis is a superficial dermatophyte infection of the skin commonly found in tropical regions due to hot and humid environmental conditions. This disease is characterized by well-defined, scaly, annular lesions accompanied by pruritus, and is influenced by various risk factors such as age, gender, personal hygiene, and comorbidities. Various topical and systemic antifungal therapies have been used in the treatment of tinea corporis, but their effectiveness can vary depending on the clinical presentation and patient characteristics. This study is a literature review conducted by reviewing research articles related to the clinical presentation and effectiveness of antifungal therapy in cases of tinea corporis in tropical regions. The literature search was conducted through Google Scholar, PubMed, ResearchGate, Elsevier, and NCBI databases. A total of 10 articles published between 2021 and 2025 that met the inclusion criteria were analyzed descriptively and synthesized narratively. The review indicates that Trichophyton rubrum is the most common cause of tinea corporis. Topical antifungal therapy is effective in mild to moderate cases, while systemic therapies such as itraconazole, terbinafine, and griseofulvin are more effective in extensive, chronic, or resistant cases. The combination of topical and systemic therapy shows a higher cure rate and reduces recurrence rates. The clinical presentation and response to therapy for tinea corporis in tropical regions are influenced by environmental factors, patient characteristics, and the choice of antifungal regimen. Appropriate clinical evaluation and rational use of antifungal therapy, both topical and systemic, are crucial for achieving optimal cure and preventing recurrence.

Article Details

How to Cite
Abduh, A. P., Abdi, D. A. ., & Setiawati, S. . (2026). Evaluation of the Clinical Picture and Effectiveness of Antifungal Therapy in Tinea Corporis Cases in Tropical Areas: Literature Review . Journal of Community Health Provision, 6(1), 1-16. https://doi.org/10.55885/jchp.v6i1.856
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References

Ahmed, A., Mohamed, N. S., & Siddig, E. E. (2025). Exploring the Diversity and Distribution of Medico-Veterinary Fungal Diseases in Africa: Harnessing a Multisectoral One Health Strategy for Cost-Effective Prevention and Preparedness. Journal of Fungi, 11(8), 569. https://doi.org/10.3390/jof11080569

Andrulis, D. P. (1998). Access to care is the centerpiece in the elimination of socioeconomic disparities in health. Annals of internal medicine, 129(5), 412-416. https://doi.org/10.7326/0003-4819-129-5-199809010-00012

Azzahra, S., Ervianti, E., & Setiabudi, R. (2024). Clinical Patterns and Demographic Characteristics of Dermatophytosis in Surabaya. Indonesian Journal of Tropical and Infectious Disease, 12(3), 252-267. https://doi.org/10.20473/ijtid.v12i3.66511

Bhat, R. M., & Swathi, N. (2025). Missed, but Momentous: A Comprehensive Review of Neglected Tropical Skin Diseases in Southern India and their Global Impact. Clinical Dermatology Review, 9(1), 9-16. https://doi.org/10.4103/cdr.cdr_79_24

Branda, F., Ali, A. Y., Ceccarelli, G., Albanese, M., Binetti, E., Giovanetti, M., ... & Scarpa, F. (2024). Assessing the burden of neglected tropical diseases in low-income communities: challenges and solutions. Viruses, 17(1), 29. https://doi.org/10.3390/v17010029

Branda, F., Petrosillo, N., Ceccarelli, G., Giovanetti, M., De Vito, A., Madeddu, G., ... & Ciccozzi, M. (2025). Antifungal agents in the 21st century: advances, challenges, and future perspectives. Infectious Disease Reports, 17(4), 91. https://doi.org/10.3390/idr17040091

Brüggemann, R. J., & Aarnoutse, R. E. (2015). Fundament and prerequisites for the application of an antifungal TDM service. Current Fungal Infection Reports, 9(2), 122-129. https://doi.org/10.1007/s12281-015-0224-3

Chanyachailert, P., Leeyaphan, C., & Bunyaratavej, S. (2023). Cutaneous fungal infections caused by dermatophytes and non-dermatophytes: an updated comprehensive review of epidemiology, clinical presentations, and diagnostic testing. Journal of Fungi, 9(6), 669. https://doi.org/10.3390/jof9060669

Charlesworth, E. N., & Beltrani Sr, V. S. (2002). Pruritic dermatoses: overview of etiology and therapy. The American journal of medicine, 113(9), 25-33. https://doi.org/10.1016/S0002-9343(02)01434-1

Chen, X. Q., & Yu, J. (2023). Global demographic characteristics and pathogen spectrum of tinea capitis. Mycopathologia, 188(5), 433-447. https://doi.org/10.1007/s11046-023-00710-8

Chidzwondo, F., & Mutapi, F. (2024). Challenge of diagnosing acute infections in poor resource settings in Africa. AAS Open Research, 4, 28.

Chowdhary, A., Singh, A., Kaur, A., & Khurana, A. (2022). The emergence and worldwide spread of the species Trichophyton indotineae causing difficult-to-treat dermatophytosis: a new challenge in the management of dermatophytosis. PLoS pathogens, 18(9), e1010795. https://doi.org/10.1371/journal.ppat.1010795

Chung, B. Y., Um, J. Y., Kim, J. C., Kang, S. Y., Park, C. W., & Kim, H. O. (2020). Pathophysiology and treatment of pruritus in elderly. International Journal of Molecular Sciences, 22(1), 174. https://doi.org/10.3390/ijms22010174

de Oliveira Serra, M. A. A., da Silva, R. A. A., Monari, F. F., Silva, J. O. E., de Sá Junior, J. X., Silva, R. D. A. E., ... & de Araújo, M. F. M. (2023). Individual, socioeconomic and healthcare access factors influencing the delays in leprosy presentation, diagnosis and treatment: a qualitative study. Transactions of The Royal Society of Tropical Medicine and Hygiene, 117(12), 852-858. https://doi.org/10.1093/trstmh/trad056

Fiscella, K., & Williams, D. R. (2004). Health disparities based on socioeconomic inequities: implications for urban health care. Academic Medicine, 79(12), 1139-1147. https://doi.org/10.1097/00001888-200412000-00004

Fonseka, S., Bandara, D. D. J., Wickramaarachchi, D. C., Narankotuwa, N. G. K. H. H., & Kumarasiri, P. V. R. (2021). Treatment of difficult-to-treat-dermatophytosis: results of a randomized, double-blind, placebo-controlled study. The Journal of Infection in Developing Countries, 15(11), 1731-1737. https://doi.org/10.3855/jidc.14666

Ghazy, R. M., Alshaikhi, S. A., Assiri, H. A. H., Almozaini, A. A., Alhazmi, A. F., Elhasaneen, H. E. M., & Abdo, S. M. (2025). Tropical diseases and the gastrointestinal tract: an overlooked connection. Frontiers in Tropical Diseases, 6, 1612952.

Grant, S. M., & Clissold, S. P. (1989). Itraconazole: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in superficial and systemic mycoses. Drugs, 37(3), 310-344. https://doi.org/10.2165/00003495-198937030-00003

Gyapong, J. O., Gohoho, M., Manyeh, A. K., Immurana, M., & Gyapong, M. (2025). Current state and future directions of interventions for neglected tropical diseases. Nature Human Behaviour, 9(8), 1557-1570. https://doi.org/10.1038/s41562-025-02219-0

Hafeez, S. (2025). Efficacy of Terbinafine Versus Itraconazole in the Treatment of Tinea Corporis. Journal of Pakistan Association of Dermatologists, 35(2), 99-104.

Kaestle, C. E., Halpern, C. T., Miller, W. C., & Ford, C. A. (2005). Young age at first sexual intercourse and sexually transmitted infections in adolescents and young adults. American journal of epidemiology, 161(8), 774-780. https://doi.org/10.1093/aje/kwi095

Kaplan, J. E., Benson, C., Holmes, K. K., Brooks, J. T., Pau, A., Masur, H., ... & HIV Medicine Association of the Infectious Diseases Society of America. (2009). Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents. MMWR Recomm Rep, 58(4), 1-207.

Keshwania, P., Kaur, N., Chauhan, J., Sharma, G., Afzal, O., Alfawaz Altamimi, A. S., & Almalki, W. H. (2023). Superficial dermatophytosis across the world’s populations: potential benefits from nanocarrier-based therapies and rising challenges. ACS omega, 8(35), 31575-31599. https://doi.org/10.1021/acsomega.3c01988

Khurana, A., Agarwal, A., Agrawal, D., Panesar, S., Ghadlinge, M., Sardana, K., ... & Mehta, N. (2022). Effect of different itraconazole dosing regimens on cure rates, treatment duration, safety, and relapse rates in adult patients with tinea corporis/cruris: a randomized clinical trial. JAMA dermatology, 158(11), 1269-1278. https://doi.org/10.1001/jamadermatol.2022.3745

Kruithoff, C., Gamal, A., McCormick, T. S., & Ghannoum, M. A. (2023). Dermatophyte infections worldwide: increase in incidence and associated antifungal resistance. Life, 14(1), 1. https://doi.org/10.3390/life14010001

Kwizera, R., Abdolrasouli, A., Garcia-Effron, G., & Denning, D. W. (2024). Antifungal susceptibility testing: applicability of methods and strategies for improving access in resource-constrained settings. The Lancet Infectious Diseases, 24(12), e782-e793.

Lal, N. R., Basu, D., Saha, A., Ghosh, R., Verma, R., & Bandyopadhyay, D. (2023). Efficacy and safety of 250 mg versus 500 mg oral terbinafine in the treatment of tinea corporis and cruris: a randomised, assessor-blinded comparative study. Indian Journal of Dermatology, Venereology and Leprology, 89(5), 665-671.

Lewis, R. E. (2006). Decision making in antifungal monotherapy versus combination therapy. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 26(6P2), 61S-67S. https://doi.org/10.1592/phco.26.6part2.61S

Meena, S., & Bhadauria, S. (2024). Clinical Manifestations of Dermatophytoses and its Treatment: A Review. Asian Journal of Biology, 20(7), 78-89.

Naseer, M., Devi, V., Khan, K. N., Asad, N., Azhar, A., Asif, M. I. A., ... & Khan, M. A. (2025). Efficacy and Safety of Voriconazole in the Treatment of Tinea Corporis and Cruris Infections. Journal of Pakistan Association of Dermatologists, 35(1), 4-10.

Nenoff, P., Verma, S. B., Vasani, R., Burmester, A., Hipler, U. C., Wittig, F., ... & Uhrlaß, S. (2019). The current Indian epidemic of superficial dermatophytosis due to Trichophyton mentagrophytes—A molecular study. Mycoses, 62(4), 336-356. https://doi.org/10.1111/myc.12878

Nowicka, D., Bagłaj-Oleszczuk, M., & Maj, J. (2020). Infectious diseases of the skin in contact sports. Advances in Clinical and Experimental Medicine, 29(12), 1491-1495.

Rothstein, E., & Edwards, K. (2005). Health burden of pertussis in adolescents and adults. The Pediatric infectious disease journal, 24(5), S44-S47. https://doi.org/10.1097/01.inf.0000160912.58660.87

Rudramurthy, S. M., & Shaw, D. (2019). Epidemiology of superficial fungal infections in Asia. In Clinical Practice of Medical Mycology in Asia (pp. 9-37). Singapore: Springer Singapore. https://doi.org/10.1007/978-981-13-9459-1_2

Sadiq, I. Z. (2025). Combating Infectious Diseases in Low-Resource Communities: Socioeconomic, Environmental, Climate Change and Gender-Based Strategies. Journal of Preventive Medicine and Hygiene, 66(3), E341. https://doi.org/10.15167/2421-4248/jpmh2025.66.3.3508

Sahoo, A. K., & Mahajan, R. (2016). Management of tinea corporis, tinea cruris, and tinea pedis: A comprehensive review. Indian dermatology online journal, 7(2), 77-86. https://doi.org/10.4103/2229-5178.178099

Saleh, Y. S., Kubaisi, T. A., & Mohammad, B. I. (2025). Oral Itraconazole and Terbinafine vs. Itraconazole as a Novel Regimen for the Newly Emergent Chronic Tinea: A Comparative Clinical Study. Iraqi Journal of Pharmaceutical Sciences, 34(3), 119-130. https://doi.org/10.31351/vol34iss3pp119-130

Schaller, M., Friedrich, M., Papini, M., Pujol, R. M., & Veraldi, S. (2016). Topical antifungal‐corticosteroid combination therapy for the treatment of superficial mycoses: conclusions of an expert panel meeting. Mycoses, 59(6), 365-373. https://doi.org/10.1111/myc.12481

Sharma, B., & Nonzom, S. (2021). Superficial mycoses, a matter of concern: Global and Indian scenario‐an updated analysis. Mycoses, 64(8), 890-908. https://doi.org/10.1111/myc.13264

Tanriati, I., Hadi, S., Sanyoto, D. D., Savitri, D., & Rahmiati, R. (2023). Profil pasien tinea korporis di poliklinik kulit dan kelamin RSUD Ulin Banjarmasin periode 2019-2021. Homeostasis, 6(1). https://doi.org/10.20527/ht.v6i1.8786

Urban, K., Chu, S., Scheufele, C., Giesey, R. L., Mehrmal, S., Uppal, P., & Delost, G. R. (2021). The global, regional, and national burden of fungal skin diseases in 195 countries and territories: A cross-sectional analysis from the Global Burden of Disease Study 2017. JAAD international, 2, 22-27. https://doi.org/10.1016/j.jdin.2020.10.003

Vernekar, P. P., Prabhu, S. R., Jain, P. A., & Naveen, K. N. (2024). Clinicomycological Study of Dermatophyte Infections in Patients Attending Dermatology Outpatient Department in a Tertiary Care Hospital. Clinical Dermatology Review, 8(2), 120-126. https://doi.org/10.4103/cdr.cdr_112_22

Wang, N., Cao, F., Liu, F., Jia, Y., Wang, J., Bao, C., ... & Cheng, Y. (2015). The effect of socioeconomic status on health-care delay and treatment of esophageal cancer. Journal of translational medicine, 13(1), 241. https://doi.org/10.1186/s12967-015-0579-9

Warsi, S., Siddique, A., & Terrill, T. H. (2025). Tinea capitis/Tinea corporis (Microsporum spp.). The One Health Model as Applied to Zoonotic Diseases, 181-186. https://doi.org/10.1002/9781119985853.ch5.1

Yamada, T., Chen, C. C., Murata, C., Hirai, H., Ojima, T., Kondo, K., & Harris III, J. R. (2015). Access disparity and health inequality of the elderly: unmet needs and delayed healthcare. International journal of environmental research and public health, 12(2), 1745-1772. https://doi.org/10.3390/ijerph120201745