Breast Cancer in Pregnancy: A Case Report of a Mammary Ulcer in a 37-Year-Old Woman
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Afifi, A. M., Saad, A. M., Al‐Husseini, M. J., Elmehrath, A. O., Northfelt, D. W., & Sonbol, M. B. (2020). Causes of death after breast cancer diagnosis: A US population‐based analysis. Cancer, 126(7), 1559-1567. https://doi.org/10.1002/cncr.32648
Akhlaqi, M., Ghofrani, A., Najdi, N., Ranjkesh, M., & Almasi-Hashiani, A. (2025). A systematic review and meta-analysis of pregnancy-associated breast cancer incidence rate. BMC cancer, 25(1), 660. https://doi.org/10.1186/s12885-025-14091-2
Akram, M., Iqbal, M., Daniyal, M., & Khan, A. U. (2017). Awareness and current knowledge of breast cancer. Biological research, 50(1), 33. https://doi.org/10.1186/s40659-017-0140-9
Amant, F., Lefrère, H., Borges, V. F., Cardonick, E., Lambertini, M., Loibl, S., ... & Schedin, P. (2021). The definition of pregnancy-associated breast cancer is outdated and should no longer be used. The Lancet Oncology, 22(6), 753-754.
Anwar, S. L., Raharjo, C. A., Herviastuti, R., Dwianingsih, E. K., Setyoheriyanto, D., Avanti, W. S., ... & Wulaningsih, W. (2019). Pathological profiles and clinical management challenges of breast cancer emerging in young women in Indonesia: a hospital-based study. BMC Women's Health, 19(1), 28. https://doi.org/10.1186/s12905-019-0724-3
Aprilianty, D. A., Rafidah, R., Suhrawardi, S., & Rusmilawaty, R. (2024). Studi Literatur Faktor Risiko Yang Berhubungan Dengan Kejadian Kanker Payudara Pada Wanita. Jurnal Cakrawala Ilmiah, 3(9), 2473-2486.
Arlina, A. (2024). Understanding and Perceptions of Women of Reproductive Age towards Breast Self-Examination as an Effort for Early Detection of Breast Cancer. Advances in Healthcare Research, 2(2), 130-140. https://doi.org/10.60079/ahr.v2i2.539
Awaliyah, N., Pradjatmo, H., & Kusnanto, H. (2017). Penggunaan kontrasepsi hormonal dan kejadian kanker payudara di rumah sakit Dr. Sardjito. Berita Kedokteran Masyarakat, 33(10), 487-494.
Bajpai, J., Simha, V., Shylasree, T. S., Sarin, R., Pathak, R., Popat, P., ... & Gupta, S. (2021). Pregnancy associated breast cancer (PABC): Report from a gestational cancer registry from a tertiary cancer care centre, India. The Breast, 56, 88-95. https://doi.org/10.1016/j.breast.2021.02.005
Barbagianni, M. S., & Gouletsou, P. G. (2023). Modern imaging techniques in the study and disease diagnosis of the mammary glands of animals. Veterinary Sciences, 10(2), 83. https://doi.org/10.3390/vetsci10020083
Bingliang, C., Jinhao, L., Haijian, L., Yi, J., Zhifeng, H., & Chuansheng, Y. (2025). Global, Regional, and National Burden of Breast Cancer Attributable to Low Physical Activity in Women of Reproductive Age: Historical Trends from 1990 to 2021 and Projections to 2035. Archives of Iranian Medicine, 28(11), 630-641. https://doi.org/10.34172/aim.34998
Biswas, S. K., Banerjee, S., Baker, G. W., Kuo, C. Y., & Chowdhury, I. (2022). The mammary gland: basic structure and molecular signaling during development. International Journal of Molecular Sciences, 23(7), 3883. https://doi.org/10.3390/ijms23073883
Cai, Y., Dai, F., Ye, Y., & Qian, J. (2025). The global burden of breast cancer among women of reproductive age: a comprehensive analysis. Scientific Reports, 15(1), 9347. https://doi.org/10.1038/s41598-025-93883-9
Cathcart-Rake, E. J., Ruddy, K. J., Bleyer, A., & Johnson, R. H. (2021). Breast cancer in adolescent and young adult women under the age of 40 years. JCO oncology practice, 17(6), 305-313. https://doi.org/10.1200/OP.20.00793
Choridah, L., Icanervilia, A. V., de Wit, M. J. M., van Asselt, A. D., Kurniawan, W. T., Fahmi, Y. I., & Rengganis, A. A. (2021). Knowledge and acceptance towards mammography as breast cancer screening tool among Yogyakarta women and health care providers (mammography screening in Indonesia). Journal of Cancer Education, 36(3), 532-537. https://doi.org/10.1007/s13187-019-01659-3
Chotai, N., Renganathan, R., Uematsu, T., Wang, J., Zhu, Q., Rahmat, K., ... & Chang, J. M. (2025). Breast cancer screening in asian countries: epidemiology, screening practices, outcomes, challenges, and future directions. Korean Journal of Radiology, 26(8), 743. https://doi.org/10.3348/kjr.2025.0338
Contiero, P., Boffi, R., Borgini, A., Fabiano, S., Tittarelli, A., Mian, M., ... & MAPACA Working Group. (2023). Causes of death in women with breast cancer: a risks and rates study on a population-based cohort. Frontiers in Oncology, 13, 1270877. https://doi.org/10.3389/fonc.2023.1270877
Dewi, T. K., Massar, K., Ardi, R., & Ruiter, R. A. (2021). Determinants of early breast cancer presentation: a qualitative exploration among female survivors in Indonesia. Psychology & Health, 36(12), 1427-1440. https://doi.org/10.1080/08870446.2020.1841765
Galati, F., Magri, V., Arias-Cadena, P. A., Moffa, G., Rizzo, V., Pasculli, M., ... & Pediconi, F. (2023). Pregnancy-associated breast cancer: a diagnostic and therapeutic challenge. Diagnostics, 13(4), 604. https://doi.org/10.3390/diagnostics13040604
Hannan, F. M., Elajnaf, T., Vandenberg, L. N., Kennedy, S. H., & Thakker, R. V. (2023). Hormonal regulation of mammary gland development and lactation. Nature Reviews Endocrinology, 19(1), 46-61. https://doi.org/10.1038/s41574-022-00742-y
Houghton, S. C., & Hankinson, S. E. (2021). Cancer progress and priorities: breast cancer. Cancer epidemiology, biomarkers & prevention, 30(5), 822-844. https://doi.org/10.1158/1055-9965.EPI-20-1193
Hughes, K. (2021). Development and pathology of the equine mammary gland. Journal of Mammary Gland Biology and Neoplasia, 26(2), 121-134. https://doi.org/10.1007/s10911-020-09471-2
Icanervilia, A. V., Choridah, L., Van Asselt, A. D., Vervoort, J. P., Postma, M. J., Rengganis, A. A., & Kardinah, K. (2023). Early detection of breast cancer in Indonesia: barriers identified in a qualitative study. Asian Pacific journal of cancer prevention: APJCP, 24(8), 2749. https://doi.org/10.31557/APJCP.2023.24.8.2749
Jiang, N. (2025). Global burden and future trends of gastric cancer in women of reproductive age: estimates from the GBD 2021 Study, 1990–2050. Frontiers in Oncology, 15, 1616936. https://doi.org/10.3389/fonc.2025.1616936
Johansson, A. L., & Stensheim, H. (2020). Epidemiology of pregnancy-associated breast cancer. Diseases of the Breast during Pregnancy and Lactation, 75-79. https://doi.org/10.1007/978-3-030-41596-9_9
Kim, J., Harper, A., McCormack, V., Sung, H., Houssami, N., Morgan, E., ... & Fidler-Benaoudia, M. M. (2025). Global patterns and trends in breast cancer incidence and mortality across 185 countries. Nature medicine, 31(4), 1154-1162.
Krishnamurthy, J. (2025). Pregnancy-associated breast cancer: key concepts for optimizing diagnosis and treatment. JCO Oncology Practice, 21(3), 275-277.
Linos, E., Spanos, D., Rosner, B. A., Linos, K., Hesketh, T., Qu, J. D., ... & Colditz, G. A. (2008). Effects of reproductive and demographic changes on breast cancer incidence in China: a modeling analysis. Journal of the National Cancer Institute, 100(19), 1352-1360. https://doi.org/10.1093/jnci/djn305
Londero, A. P., Bertozzi, S., Xholli, A., Cedolini, C., & Cagnacci, A. (2024). Breast cancer and the steadily increasing maternal age: are they colliding?. BMC Women's Health, 24(1), 286. https://doi.org/10.1186/s12905-024-03138-4
Martín Cameán, M., Jaunarena, I., Sánchez-Méndez, J. I., Martín, C., Boria, F., Martín, E., ... & Hernández Gutiérrez, A. (2024). Survival in pregnancy-associated breast cancer patients compared to non-pregnant controls. Reproductive Biology and Endocrinology, 22(1), 34. https://doi.org/10.1186/s12958-024-01206-w
Ng, B., Puspitaningtyas, H., Wiranata, J. A., Hutajulu, S. H., Widodo, I., Anggorowati, N., ... & Sripan, P. (2023). Breast cancer incidence in Yogyakarta, Indonesia from 2008–2019: A cross-sectional study using trend analysis and geographical information system. Plos one, 18(7), e0288073. https://doi.org/10.1371/journal.pone.0288073
Octovianus, J., Kuntari, S., & Djatmiko, A. (2015). Pregnancy Associated Breast Cancer Di Rumah Sakit Onkologi Surabaya 2006 2014. Indonesian Journal of Cancer, 9(2), 59-64.
Paris, I., Di Giorgio, D., Carbognin, L., Corrado, G., Garganese, G., Franceschini, G., ... & Scambia, G. (2021). Pregnancy-associated breast cancer: a multidisciplinary approach. Clinical breast cancer, 21(1), e120-e127. https://doi.org/10.1016/j.clbc.2020.07.007
Polyak, K., & Kalluri, R. (2010). The role of the microenvironment in mammary gland development and cancer. Cold Spring Harbor perspectives in biology, 2(11), a003244.
Proussaloglou, E. M., Blanco Jr, L. Z., & Siziopikou, K. P. (2023). Updates in the pathology of pregnancy associated breast cancer (PABC). Pathology-Research and Practice, 244, 154413. https://doi.org/10.1016/j.prp.2023.154413
Pyle, C., Hill, M., Sharafi, S., Forton, C., & Sohaey, R. (2023). Pregnancy-associated breast cancer: why breast imaging during pregnancy and lactation matters. Journal of Breast Imaging, 5(6), 732-743. https://doi.org/10.1093/jbi/wbad074
Setyowibowo, H., Purba, F. D., Hunfeld, J. A., Iskandarsyah, A., Sadarjoen, S. S., Passchier, J., & Sijbrandij, M. (2018). Quality of life and health status of Indonesian women with breast cancer symptoms before the definitive diagnosis: A comparison with Indonesian women in general. PloS one, 13(7), e0200966. https://doi.org/10.1371/journal.pone.0200966
Solikhah, S., Perwitasari, D. A., & Rejeki, D. S. S. (2022). Geographic characteristics of various cancers in Yogyakarta Province, Indonesia: a spatial analysis at the community level. Asian Pacific journal of cancer prevention: APJCP, 23(4), 1231. https://doi.org/10.31557/APJCP.2022.23.4.1231
Solikhah, S., Promthet, S., & Hurst, C. (2019). Awareness level about breast cancer risk factors, barriers, attitude and breast cancer screening among Indonesian women. Asian Pacific journal of cancer prevention: APJCP, 20(3), 877. https://doi.org/10.31557/APJCP.2019.20.3.877
Sun, P., Yu, C., Yin, L., Chen, Y., Sun, Z., Zhang, T., ... & Wan, Z. (2024). Global, regional, and national burden of female cancers in women of child-bearing age, 1990–2021: analysis of data from the global burden of disease study 2021. EClinicalMedicine, 74.
Susanto, S., Nugroho, S. A., & Handoko, Y. T. (2022). Pengetahuan Ibu tentang Penyakit Kanker Payudara Berhubungan dengan Tingkat Kecemasan pada Pasien Pre Operasi Kanker Payudara. Jurnal Penelitian Perawat Profesional, 4(2), 589-598.
Torre, L. A., Islami, F., Siegel, R. L., Ward, E. M., & Jemal, A. (2017). Global cancer in women: burden and trends. Cancer epidemiology, biomarkers & prevention, 26(4), 444-457. https://doi.org/10.1158/1055-9965.EPI-16-0858
Wahidin, M., Febrianti, R., Susanty, F., & Hasanah, S. R. (2022). Twelve years implementation of cervical and breast cancer screening program in Indonesia. Asian Pacific journal of cancer prevention: APJCP, 23(3), 829. https://doi.org/10.31557/APJCP.2022.23.3.829
Watson, C. J. (2006). Key stages in mammary gland development-Involution: apoptosis and tissue remodelling that convert the mammary gland from milk factory to a quiescent organ. Breast Cancer Research, 8(2), 203. https://doi.org/10.1186/bcr1401
Yumaeroh, A. N., Intarti, W. D., & Aritonang, T. R. (2023). Hubungan pengetahuan tentang kanker payudara terhadap perilaku pencegahan kanker payudara pada wanita usia subur di pmb afiin nanik yumaeroh Bekasi tahun 2023. Jurnal Bina Cipta Husada: Jurnal Kesehatan Dan Science, 19(2), 1-13.
Zhu, J. W., Charkhchi, P., Adekunte, S., & Akbari, M. R. (2023). What is known about breast cancer in young women?. Cancers, 15(6), 1917. https://doi.org/10.3390/cancers15061917