Pathophysiological Mechanisms Linking Myocardial Infarction to Cardiac Arrest: A Literature Review

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Published: Jun 11, 2026
DOI: https://doi.org/10.55885/jchp.v6i2.978
Keywords:
Myocardial Infarction, Cardiac Arrest, Pathophysiology

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Andi Suleha
Department of Medical Profession, Faculty of Medicine, Universitas Muslim Indonesia, Indonesia
Akina Maulidhany Tahir
Departement of Cardiovascular, Faculty of Medicine, Universitas Muslim Indonesia, Indonesia
Fadillah Maricar
Departement of Cardiovascular, Faculty of Medicine, Universitas Muslim Indonesia, Indonesia
Priscilla Sasmita Rido
Departement of Cardiovascular, Faculty of Medicine, Universitas Muslim Indonesia, Indonesia
Nurhikmawati
Departement of Cardiovascular, Faculty of Medicine, Universitas Muslim Indonesia, Indonesia

Abstract

Myocardial infarction (MI) is a leading cause of cardiac arrest and sudden cardiac death worldwide. The pathophysiological link involves complex interactions between cellular, electrophysiological, hemodynamic, and neurohormonal mechanisms. The objective of the research to comprehensively review the pathophysiological mechanisms linking myocardial infarction to cardiac arrest. The methods of the research was a descriptive-analytic literature review was conducted using PubMed, ScienceDirect, SpringerLink, and Google Scholar databases (2021–2025). Study selection followed PRISMA guidelines. The results of the showed that eight studies were included. Key mechanisms include myocardial ischemia leading to ATP depletion and acidosis, ionic imbalance, arrhythmogenic substrate formation, sympathetic overactivation, inflammatory response and oxidative stress, and hemodynamic collapse. Cardiac arrest following MI is primarily driven by fatal ventricular arrhythmias and pump failure. Understanding these mechanisms is essential for improving prevention and management strategies.

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How to Cite
Suleha, A. ., Tahir, A. M. ., Maricar, F. ., Rido, P. S. ., & Nurhikmawati, N. (2026). Pathophysiological Mechanisms Linking Myocardial Infarction to Cardiac Arrest: A Literature Review. Journal of Community Health Provision, 6(2), 385-396. https://doi.org/10.55885/jchp.v6i2.978
Issue
Vol. 6 No. 2 (2026): Journal of Community Health Provision
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Articles
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This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

References

Abbas, A., Raza, A., Ullah, M., Hendi, A. A., Akbar, F., Khan, S. U., ... & Rizg, W. Y. (2023). A comprehensive review: epidemiological strategies, catheterization and biomarkers used as a bioweapon in diagnosis and management of cardio vascular diseases. Current Problems in Cardiology, 48(7), 101661. https://doi.org/10.1016/j.cpcardiol.2023.101661

Acharya, U. R., Fujita, H., Oh, S. L., Hagiwara, Y., Tan, J. H., & Adam, M. (2017). Application of deep convolutional neural network for automated detection of myocardial infarction using ECG signals. Information Sciences, 415, 190–198. https://doi.org/10.1016/j.ins.2017.06.027

Alzahrani, R. S. M., Almotairi, R. A. G., Alessa, A. M. A., Alsahafi, W. A. H., Alabdali, N. M., Almotairi, M. A., ... & Algmani, F. M. S. (2025). Prehospital Cardiac Arrest Management: A Narrative Review. The Review of Diabetic Studies, 10-29. https://doi.org/10.1016/j.jen.2025.12.001

American Heart Association. (2020). Highlights of the 2020 American Heart Association guidelines for CPR and ECC. American Heart Association.

American Heart Association. (2026). 2026 heart disease and stroke statistics update fact sheet at a glance [Preprint].

Buja, L. M. (2023). Pathobiology of myocardial ischemia and reperfusion injury: Models, modes, molecular mechanisms, modulation, and clinical applications. Cardiology in Review, 31(5), 252–264. https://doi.org/10.1097/crd.0000000000000440

Chen, L., Luo, S., Feng, M., Chandra, A., Baizabal-Carvallo, J. F., Mofatteh, M., ... & Liao, X. (2025). Decoding the link between ischemic stroke and myocardial infarction: a pathophysiological and clinical perspective. European Journal of Medical Research, 30(1), 984. https://doi.org/10.1186/s40001-025-03221-y

Corrall, S., Laws, S., & Rice, A. (2023). Low-voltage electrical injuries and the electrocardiogram: is a ‘normal’electrocardiogram sufficient for safe discharge from care? A systematic review. British paramedic journal, 8(3), 27-36. https://doi.org/10.29045/14784726.2023.12.8.3.27

Del Buono, M. G., Moroni, F., Montone, R. A., Azzalini, L., Sanna, T., & Abbate, A. (2022). Ischemic cardiomyopathy and heart failure after acute myocardial infarction. Current Cardiology Reports, 24(10), 1505–1515. https://doi.org/10.1007/s11886-022-01766-6

Frampton, J., Ortengren, A. R., & Zeitler, E. P. (2023). Arrhythmias after acute myocardial infarction. The Yale Journal of Biology and Medicine, 96(1), 83–92. https://doi.org/10.59249/LSWK8578

Gamberini, L., Carinci, V., Pallavicini, P., Rovera, M., Tartaglione, M., Gioachin, R., ... & Sirugo, P. (2025). Prehospital management of supraventricular tachycardia: a multicentre study of current practices with a subgroup propensity score-based comparison of adenosine and electrical cardioversion in unstable patients. Resuscitation, 215, 110707. https://doi.org/10.1016/j.resuscitation.2025.110707

Greif, R., Lauridsen, K. G., Djärv, T., Ek, J. E., Monnelly, V., Monsieurs, K. G., ... & Kiebooms, E. (2025). European Resuscitation Council guidelines 2025 executive summary. Resuscitation, 215, 110770. https://doi.org/10.1016/j.resuscitation.2025.110770

Heusch, G. (2024). Myocardial ischemia reperfusion: Translational pathophysiology of ischemic heart disease. Med, 5(1), 10–31. https://doi.org/10.1016/j.medj.2023.12.007

Hørsdal, O. K., Frederiksen, P. H., Helgestad, O. K. L., Ravn, H. B., Møller, J. E., Wiggers, H., ... & Berg Hansen, K. (2025). The immediate cardiovascular and mitochondrial response in ischemic cardiogenic shock. Journal of Cardiovascular Translational Research, 1–14. https://doi.org/10.1007/s12265-025-10647-6

Husna, A. F., & Fauzan, R. (2025). Diagnosis dan tata laksana cardiac arrest berdasarkan panduan AHA 2020: Tinjauan literatur terkini. Inovasi Kesehatan Global, 2(4), 185–198. https://doi.org/10.62383/ikg.v2i4.2373

Katsioupa, M., Kourampi, I., Oikonomou, E., Tsigkou, V., Theofilis, P., Charalambous, G., ... & Tousoulis, D. (2023). Novel biomarkers and their role in the diagnosis and prognosis of acute coronary syndrome. Life, 13(10), 1992. https://doi.org/10.3390/life13101992

Laksono, S., & Harsas, N. A. (2022). Arrhythmia in acute coronary syndrome: Mini review. Al Iqra Medical Journal, 5(1), 41–47. https://doi.org/10.1016/j.hrtlng.2013.07.010

Lazzarin, T., Tonon, C. R., Martins, D., Fávero Jr, E. L., Baumgratz, T. D., Pereira, F. W. L., ... & Minicucci, M. F. (2022). Post cardiac arrest mechanisms management and future perspectives. Journal of Clinical Medicine, 12(1), 259. https://doi.org/10.3390/jcm12010259

Leancă, S. A., Crișu, D., Petriș, A. O., Afrăsânie, I., Genes, A., Costache, A. D., ... & Costache, I. I. (2022). Left ventricular remodeling after myocardial infarction: from physiopathology to treatment. Life, 12(8), 1111. https://doi.org/10.3390/life12081111

Lei, M., Salvage, S. C., Jackson, A. P., & Huang, C. L. H. (2024). Cardiac arrhythmogenesis: roles of ion channels and their functional modification. Frontiers in physiology, 15, 1342761. https://doi.org/10.3389/fphys.2024.1342761

Lott, C., Truhlář, A., Alfonzo, A., Barelli, A., González-Salvado, V., Hinkelbein, J., ... & Schmitz, J. (2021). European Resuscitation Council guidelines 2021: Cardiac arrest in special circumstances. Resuscitation, 161, 152–219. https://doi.org/10.1016/j.resuscitation.2021.02.011

Martinez-Navarro, H., Zhou, X., & Rodriguez, B. (2025). Mechanisms and implications of electrical heterogeneity in cardiac function in ischemic heart disease. Annual Review of Physiology, 87(1), 25-51. https://doi.org/10.1146/annurev-physiol-042022-020541

Maurovich-Horvat, P., Bosserdt, M., Kofoed, K. F., Rieckmann, N., Benedek, T., Donnelly, P., ... & Dewey, M. (2022). CT or invasive coronary angiography in stable chest pain. New England Journal of Medicine, 386(17), 1591-1602. https://doi.org/10.1056/nejmoa2200963

Menon, T., Ogbu, I., & Kalra, D. K. (2024). Sleep-Disordered Breathing and Cardiac Arrhythmias. Journal of Clinical Medicine, 13(22), 6635. https://doi.org/10.1056/nejmoa2200963

Merchant, R. M., Becker, L. B., Brooks, S. C., Chan, P. S., Del Rios, M., McBride, M. E., ... & American Heart Association. (2024). The American Heart Association emergency cardiovascular care 2030 impact goals and call to action to improve cardiac arrest outcomes: A scientific statement from the American Heart Association. Circulation, 149(8), e914–e933. https://doi.org/10.1161/cir.0000000000001196

Moras, E., Yakkali, S., Gandhi, K. D., Virk, H. U. H., Alam, M., Zaid, S., ... & Krittanawong, C. (2024). Complications in acute myocardial infarction: Navigating challenges in diagnosis and management. Hearts, 5(1), 122-141. https://doi.org/10.3390/hearts5010009

Mugnai, G., Genovese, D., Tomasi, L., & Ribichini, F. (2025). The role of implantable cardioverter-defibrillators in the elderly. Progress in Cardiovascular Diseases. https://doi.org/10.1016/j.pcad.2025.12.002

Nikolovski, S. S., Lazic, A. D., Fiser, Z. Z., Obradovic, I. A., Tijanic, J. Z., Raffay, V., ... & Tijanic, J. (2024). Recovery and survival of patients after out-of-hospital cardiac arrest: A literature review showcasing the big picture of intensive care unit-related factors. Cureus, 16(2). https://doi.org/10.7759/cureus.54827

Panchal, A. R., Bartos, J. A., Wyckoff, M. H., Drennan, I. R., Mahgoub, M., Schexnayder, S. M., ... & Del Rios, M. (2025). Part 2: Evidence evaluation and guidelines development. Circulation, 152(16 Suppl. 2), S313–S322. https://doi.org/10.1161/CIR.0000000000001373

Plott, C., Harb, T., Arvanitis, M., Gerstenblith, G., Blumenthal, R., & Leucker, T. (2024). Neurocardiac axis physiology and clinical applications. IJC Heart & Vasculature, 54, 101488. https://doi.org/10.1016/j.ijcha.2024.101488

Sirait, N. E., Larasati, T. A., Azka, L., & Saftarina, F. (2025). Systematic literature review: Validitas prognostik NIHSS sebagai prediktor luaran fungsional pada pasien stroke tinjauan periode 2020–2025. Journal of Medical Practice and Research, 1(2), 1–9. https://doi.org/10.65310/4rte7j40

Song, T., Hui, W., Huang, M., Guo, Y., Yu, M., Yang, X., ... & Chen, X. (2024). Dynamic changes in ion channels during myocardial infarction and therapeutic challenges. International journal of molecular sciences, 25(12), 6467. https://doi.org/10.3390/ijms25126467

Tabi, M., Perel, N., Taha, L., Amsalem, I., Hitter, R., Maller, T., ... & Jerusalem Platelets Thrombosis and Intervention in Cardiology Study Group. (2024). Out of hospital cardiac arrest new insights and a call for a worldwide registry and guidelines. BMC Emergency Medicine, 24(1), 140. https://doi.org/10.1186/s12873-024-01060-4

Taghdiri, A. (2024). Inflammation and arrhythmogenesis: A narrative review of the complex relationship. International Journal of Arrhythmia, 25(1), 4. https://doi.org/10.1186/s42444-024-00110-z

Thomas, K. S., Puthooran, D. M., Edpuganti, S., Reddem, A. L., Jose, A., & Akula, S. S. M. (2025). Reperfusion injury in STEMI: a double-edged sword. The Egyptian Heart Journal, 77(1), 83. https://doi.org/10.1186/s43044-025-00683-7

Tsalamandris, S., Koliastasis, L., Miliou, A., Oikonomou, E., Papageorgiou, N., Antonopoulos, A., ... & Tousoulis, D. (2025). Endothelial function and pro inflammatory cytokines as prognostic markers in acute coronary syndromes. Diagnostics, 15(8), 1033. https://doi.org/10.3390/diagnostics15081033

Wallentin, L., Eriksson, N., Olszowka, M., Grammer, T. B., Hagström, E., Held, C., ... & Siegbahn, A. (2021). Plasma proteins associated with cardiovascular death in patients with chronic coronary heart disease: A retrospective study. PLoS Medicine, 18(1), e1003513. https://doi.org/10.1371/journal.pmed.1003513

Yu, T. (2025). Neurocardiac crosstalk: Sympathetic remodeling and arrhythmogenesis after myocardial infarction. Current Issues in Molecular Biology, 47(12), 1037. https://doi.org/10.3390/cimb47121037

Zheng, M., Zhou, Z., Deng, K. Q., Zhang, H., Zeng, Z., Zhang, Y., ... & Lu, Z. (2025). Ventricular arrhythmias and myocardial infarction: Electrophysiological and neuroimmune mechanisms. Biomedicines, 13(6), 12 90. https://doi.org/10.3390/biomedicines13061290